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ESTRONE (E1)
CHILDREN*
1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
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Tanner Stages#
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Mean Age
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Reference Range
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Stage I (>14 days and prepubertal)
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7.1 years
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Undetectable-16 pg/mL
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Stage II
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11.5 years
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Undetectable-22 pg/mL
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Stage III
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13.6 years
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10-25 pg/mL
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Stage IV
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15.1 years
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10-46 pg/mL
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Stage V
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18 years
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10-60 pg/mL
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#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (+/- 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females
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Tanner Stages#
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Mean Age
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Reference Range
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Stage I (>14 days and prepubertal)
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7.1 years
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Undetectable-29 pg/mL
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Stage II
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10.5 years
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10-33 pg/mL
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Stage III
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11.6 years
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15-43 pg/mL
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Stage IV
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12.3 years
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16-77 pg/mL
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Stage V
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14.5 years
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17-200 pg/mL
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#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (+/- 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
*The reference ranges for children are based on the published literature(1,2), cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
ADULTS
Males: 10-60 pg/mL
Females
Premenopausal: 17-200 pg/mL
Postmenopausal: 7-40 pg/mL
Conversion factor
E1: pg/mL x 3.704=pmol/L (molecular weight=270)
ESTRADIOL (E2)
CHILDREN*
1-14 days: Estradiol levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
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Tanner Stages#
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Mean Age
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Reference Range
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Stage I (>14 days and prepubertal)
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7.1 years
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Undetectable-13 pg/mL
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Stage II
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12.1 years
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Undetectable-16 pg/mL
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Stage III
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13.6 years
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Undetectable-26 pg/mL
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Stage IV
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15.1 years
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Undetectable-38 pg/mL
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Stage V
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18 years
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10-40 pg/mL
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#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (+/- 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females
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Tanner Stages#
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Mean Age
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Reference Range
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Stage I (>14 days and prepubertal)
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7.1 years
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Undetectable-20 pg/mL
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Stage II
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10.5 years
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Undetectable-24 pg/mL
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Stage III
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11.6 years
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Undetectable-60 pg/mL
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Stage IV
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12.3 years
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15-85 pg/mL
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Stage V
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14.5 years
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15-350 pg/mL**
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#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (+/- 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
*The reference ranges for children are based on the published literature(1,2), cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
ADULTS
Males: 10-40 pg/mL
Females
Premenopausal: 15-350 pg/mL**
Postmenopausal: <10 pg/mL
**E2 levels vary widely through the menstrual cycle.
Conversion factor
E2: pg/mL x 3.676=pmol/L (molecular weight=272)
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