ACYLGLYCINES, QUANTITATIVE, URINE

test app

TEST NAME: ACYLGLYCINES, QUANTITATIVE, URINE

Diagnostic specificity of inborn errors of metabolism via urine acylglycine testing is useful only for the selected inborn errors of metabolism; it is recommended that urine organic acids be ordered and run simultaneously due to the limited number of metabolites included in this urine acylglycine test

Testing Algorithm: The following algorithm is available if needed

- "Newborn Screening Follow-up for Elevated C5-OH"

LAB DEPT: Core Lab Sendouts

SPECIMEN REQUIREMENTS

Specimen Type:	Random Urine
Container/Tube
Preferred/Acceptable:	A clean, plastic screw-cap urine collection container with no preservative.
Collection Volume:	10.0 mL (minimum 4.0 mL)
Patient Preparation:	None
Sample Rejection:	Mislabeled or unlabeled specimens.
Special Instructions:	Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information and send with specimen to lab. Send to lab promptly

LOGISTICS

Test Availability:	Daily
Turnaround Time:	4-7 days
Test set-up:	Monday, Wednesday, Friday
Lab Testing Section:	Send-outs
Referred to:	Mayo Medical Laboratories / Test ID: AGU20

INTERPRETIVE

Reference Range:	n-Acetylglycine:< or =3.50 mg/g Creatinine n-Propionylglycine:< or =2.25 mg/g Creatinine Isobutyrylglycine:< or =3.00 mg/g Creatinine Ethylmalonic acid:< or =25.00 mg/g Creatinine n-Butyrylglycine:< or =2.50 mg/g Creatinine 2-Methylsuccinic acid:< or =9.00 mg/g Creatinine 2-Methylbutyrylglycine:< or =2.00 mg/g Creatinine Isovalerylglycine:< or =8.00 mg/g Creatinine Glutaric acid:< or =8.00 mg/g Creatinine 3-Methylcrotonylglycine:< or =2.25 mg/g Creatinine n-Tiglylglycine:< or =9.00 mg/g Creatinine 3-Methylglutaconic acid:< or =25.00 mg/g Creatinine n-Hexanoylglycine:< or =2.00 mg/g Creatinine n-Octanoylglycine:< or =2.00 mg/g Creatinine 3-Phenylpropionylglycine:< or =2.00 mg/g Creatinine trans-Cinnamoylglycine:< or =5.50 mg/g Creatinine Suberylglycine:< or =5.00 mg/g Creatinine Dodecanedioic acid:< or =0.50 mg/g Creatinine Tetradecanedioic acid:< or =0.50 mg/g Creatinine Hexadecanedioic acid:< or =0.50 mg/g Creatinine (Reference ranges apply to all ages)
Critical Values:	Not established
Limitations:	Due to the limited number of metabolites included in the acylglycine analysis, it is recommended that Organic Acids Urine also be performed concurrently.
Methodology:	Gas Chromatography-Mass Spectrometry (GC-MS)
Test Classification:	This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

ADDITIONAL INFORMATION

For SLCH Laboratory use only

Lab Processing instructions:	If specimen is turbid or bloody, centrifuge to separate. Aliquot specimen into a 10-mL urine screw-cap transport vial. Place transport tube in dry ice to freeze immediately.
Processed Volume:	10.0 mL (minimum 4.0 mL) urine
Transport Temperature:	Frozen
Analyte Stability:	Ambient: NA Refrigerated: 9 days Frozen: 416 days
Notes:	DO NOT freeze/thaw Per Mayo: If collection volume is <4.0 and unable to collect more, submit as much specimen as possible in a single container and Mayo will determine if volume is sufficient for testing.

GENERAL INFORMATION

EPIC order name:	Miscellaneous Lab Test
Cerner order name:	Misc Ref SLC
CPT Codes:	82542
LOINC Value:	50334-2
Synonyms:
Last Updated: 05/24
Last Reviewed: 05/24