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ITRACONAZOLE, SERUM
test app
TEST NAME: ITRACONAZOLE, SERUM
LAB DEPT: Core Lab
SPECIMEN REQUIREMENTS
Specimen Type:
Blood
Container/Tube
Preferred/Acceptable:
Plain, red-top Vacutainer®.
Collection Volume:
1.0 mL (minimum 0.5 mL)
Patient Preparation:
None
Sample Rejection:
Specimens collected in gel tube(s).
Mislabeled or unlabeled specimens.
Special Instructions:
Trough specimens should be collected 30-60 minutes before next dose.
LOGISTICS
Test Availability:
Daily
Turnaround Time:
1-3 days
Test set-up:
Monday, Wednesday, & Friday; cut-off: 09:00 a.m.
Lab Testing Section:
Special Chemistry
INTERPRETIVE
Reference Range:
Itraconazole (trough)
localized infection:
>0.5 mcg/mL
systemic infection:
>1.0 mcg/mL
Hydroxyitraconazole
No therapeutic range established; activity and serum concentration are similar to parent drug.
Critical Values:
Itraconazole+Hydroxyitraconazole
(combined total): > or = 10.0 mcg/mL
Every critical result will be called back
Limitations:
Enteropathy, H2-histamine receptor blockers, hepatic enzyme inducers, and other variables can result in low to nondetectable serum levels with concomitant high risk of therapeutic failure.
Reportable range = 0.1-20 mcg/mL
Methodology:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Test Classification:
This test was developed and its performance characteristics determined by St. Louis Children's Hospital in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
ADDITIONAL INFORMATION
For SLCH Laboratory use only
Lab Processing instructions:
Centrifuge specimen to
separate within 2 hours
of collection. Aliquot serum into a conical tube.
Processed Volume:
0.5 mL (minimum 0.2 mL) serum
Analyte Stability:
PROCESSED
Ambient: NA
Refrigerated: 28 days
Frozen: NA
Notes:
Reject if collected in serum gel tube.
Specimens received after daily run should be stored in refrigerator to be analyzed next scheduled run
GENERAL INFORMATION
EPIC order name:
Itraconazole Level (EPIC Test# LAB7715)
Cerner order name:
Itraconazole
CPT Codes:
80299
LOINC Value:
Itraconazole: 10989-2
Hydroxyitraconazole: no LOINC needed
Synonyms:
Sporanox
Last Updated: 09/19
Last Reviewed: 12/23