FATTY ACIDS PROFILE, ESSENTIAL, SERUM

test app

TEST NAME: FATTY ACIDS PROFILE, ESSENTIAL, SERUM

LAB DEPT: Core Lab Sendouts

SPECIMEN REQUIREMENTS

Specimen Type:	Blood
Container/Tube
Preferred:	Gold/Red SST Vacutainer®.
Acceptable:	Plain, red-top Vacutainer®.
Collection Volume:	1.0 mL (minimum 0.5 mL)
Patient Preparation:	Fasting-overnight (12-14 hours)* ; for patients with a suspected fatty acid oxidation disorder, collect prior to next feeding as fasting is contraindicated. Patient must not consume any alcohol for 24 hours before the specimen is collected.
Sample Rejection:	Specimens that are grossly lipemic. Mislabeled or unlabeled specimens.
Special Instructions:	*For nutritional assessment, a 12- to 14-hour fast is required; however, infants or persons suspected of having a fatty acid oxidation disorder should not fast before testing owing to the possibility of acute metabolic decompensation. Instead, collect the specimen after the longest fast possible, just before feeding. In the case of a patient on total parenteral nutrition (TPN), specimen can be drawn as normal Send to lab immediately after collection. Include information regarding treatment, family history, and tentative diagnosis with specimen.

LOGISTICS

Test Availability:	Daily
Turnaround Time:	4-6 days
Test set-up:	Monday-Friday
Lab Testing Section:	Send-outs
Referred to:	Mayo Medical Laboratories (MMLI) / Test ID: FAPEP

INTERPRETIVE

Reference Range:	Lauric Acid, C12:0 <1 year: 6-190 nmol/mL 1-17 years: 5-80 nmol/mL > or =18 years: 6-90 nmol/mL Myristic Acid, C14:0 <1 year: 30-320 nmol/mL 1-17 years: 40-290 nmol/mL > or =18 years: 30-450 nmol/mL Hexadecenoic Acid, C16:1w9 <1 year: 21-69 nmol/mL 1-17 years: 24-82 nmol/mL > or =18 years: 25-105 nmol/mL Palmitoleic Acid, C16:1w7 <1 year: 20-1,020 nmol/mL 1-17 years: 100-670 nmol/mL > or =18 years: 110-1,130 nmol/mL Palmitic Acid, C16:0 <1 year: 720-3,120 nmol/mL 1-17 years: 960-3,460 nmol/mL > or =18 years: 1,480-3,730 nmol/mL Gamma-Linolenic Acid, C18:3w6 <1 year: 6-110 nmol/mL 1-17 years: 9-130 nmol/mL > or =18 years: 16-150 nmol/mL Alpha-Linolenic Acid, C18:3w3 <1 year: 10-190 nmol/mL 1-17 years: 20-120 nmol/mL > or =18 years: 50-130 nmol/mL Linoleic Acid, C18:2w6 < or =31 days: 350-2,660 nmol/mL 32 days-11 months: 1,000-3,300 nmol/mL 1-17 years: 1,600-3,500 nmol/mL > or =18 years: 2,270-3,850 nmol/mL Oleic Acid, C18:1w9 <1 year: 250-3,500 nmol/mL 1-17 years: 350-3,500 nmol/mL > or =18 years: 650-3,500 nmol/mL Vaccenic Acid, C18:1w7 <1 year: 140-720 nmol/mL 1-17 years: 320-900 nmol/mL > or =18 years: 280-740 nmol/mL Stearic Acid, C18:0 <1 year: 270-1,140 nmol/mL 1-17 years: 280-1,170 nmol/mL > or =18 years: 590-1,170 nmol/mL EPA, C20:5w3 <1 year: 2-60 nmol/mL 1-17 years: 8-90 nmol/mL > or =18 years: 14-100 nmol/mL Arachidonic Acid, C20:4w6 <1 year: 110-1,110 nmol/mL 1-17 years: 350-1,030 nmol/mL > or =18 years: 520-1,490 nmol/mL Mead Acid, C20:3w9 < or =31 days: 8-60 nmol/mL 32 days-11 months: 3-24 nmol/mL 1-17 years: 7-30 nmol/mL > or =18 years: 7-30 nmol/mL Homo-Gamma-Linolenic C20:3w6 <1 year: 30-170 nmol/mL 1-17 years: 60-220 nmol/mL > or =18 years: 50-250 nmol/mL	Arachidic Acid, C20:0 <1 year: 30-120 nmol/mL 1-17 years: 30-90 nmol/mL > or =18 years: 50-90 nmol/mL DHA, C22:6w3 <1 year: 10-220 nmol/mL 1-17 years: 30-160 nmol/mL > or =18 years: 30-250 nmol/mL DPA, C22:5w6 <1 year: 3-70 nmol/mL 1-17 years: 10-50 nmol/mL > or =18 years: 10-70 nmol/mL DPA, C22:5w3 <1 year: 6-110 nmol/mL 1-17 years: 30-270 nmol/mL > or =18 years: 20-210 nmol/mL DTA, C22:4w6 <1 year: 2-50 nmol/mL 1-17 years: 10-40 nmol/mL > or =18 years: 10-80 nmol/mL Docosenoic Acid, C22:1 <1 year: 2-20 nmol/mL 1-17 years: 4-13 nmol/mL > or =18 years: 4-13 nmol/mL Nervonic Acid, C24:1w9 <1 year: 30-150 nmol/mL 1-17 years: 50-130 nmol/mL > or =18 years: 60-100 nmol/mL Triene/Tetraene Ratio < or =31 days: 0.017-0.083 32 days-17 years: 0.013-0.050 > or =18 years: 0.010-0.038 Total Saturated Acid <1 year: 1.2-4.6 mmol/L 1-17 years: 1.4-4.9 mmol/L > or =18 years: 2.5-5.5 mmol/L Total Monounsaturated Acid <1 year: 0.3-4.6 mmol/L 1-17 years: 0.5-4.4 mmol/L > or =18 years: 1.3-5.8 mmol/L Total Polyunsaturated Acid <1 year: 1.1-4.9 mmol/L 1-17 years: 1.7-5.3 mmol/L > or =18 years: 3.2-5.8 mmol/L Total w3 <1 year: 0.0-0.4 mmol/L 1-17 years: 0.1-0.5 mmol/L > or =18 years: 0.2-0.5 mmol/L Total w6 <1 year: 0.9-4.4 mmol/L 1-17 years: 1.6-4.7 mmol/L > or =18 years: 3.0-5.4 mmol/L Total Fatty Acids <1 year: 3.3-14.0 mmol/L 1-17 years: 4.4-14.3 mmol/L > or =18 years: 7.3-16.8 mmol/L
Critical Values:	None established
Limitations:	NA
Methodology:	Gas Chromatography-Mass Spectrometry (GC-MS) Stable Isotope Dilution Analysis
Test Classification:	This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

ADDITIONAL INFORMATION

For SLCH Laboratory use only

Lab Processing instructions:	Centrifuge specimen to separate and aliquot sample into a 5-mL screw-capped, plastic vial for transport. Place aliquot tube in dry ice to freeze immediately.
Processed Volume:	0.5 mL (minimum 0.2 mL) serum
Transport Temperature:	Frozen
Analyte Stability:	PROCESSED: Ambient: NA Refrigerated: 72 hours Frozen: 92 days
Notes:	Reject due to gross lipemia DO NOT freeze thaw.

GENERAL INFORMATION

EPIC order name:	Fatty Acids Profile, Essential (EPIC Test# LAB4941)
Cerner order name:	Fatty Acids Profile, Essential
CPT Codes:	82725
LOINC Value:	43676-6
Synonyms:
Last Updated: 10/23
Last Reviewed: 10/23